This conference is the fifteenth of a series of meetings initiated in Tirrenia in 1980, and continued in Castiglione della Pescaia and La Biodola, devoted to review progresses on advanced detectors and instrumentation for physics experiments. The meeting is sponsored by the Istituto Nazionale di Fisica Nucleare (INFN), the Società Italiana di Fisica (SIF), the European Physical Society (EPS), the University of Pisa and the University of Siena.