While a tremendous amount of knowledge about the quark and gluon structure
of the nucleon and nuclei has been accumulated in the four decades since the
development of Quantum Chromodynamics, significant gaps remain, particularly
in the valence quark region where the parton momentum fraction x is large.
With the expectation of new data from the Jefferson Lab 12 GeV Science
Program, as well as from collider and neutrino experiments, it is timely to
review advances in our understanding of nucleon structure at high x and
assess the possible impact of the new data.  The workshop will discuss new
theoretical ideas and suggestions for additional studies at present and
future facilities, along with implications for related fields.

The topics to be addressed at the workshop will include:

 * Parton distribution functions at large x

 * Spin structure of the nucleon

 * Transverse momentum distributions

 * Nuclear medium modifications of parton distributions

 * Quark-hadron duality and higher twists

 * Lattice QCD and low energy models

 * Implications for new physics searches and related fields

 * Large-x Physics at the Electron-Ion Collider and future facilities